Asymmetric T lymphocyte division in the initiation of adaptive immune responses

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Title: Asymmetric T lymphocyte division in the initiation of adaptive immune responses
Author(s): Chang, John T.; Palanivel, Vikram R.; Kinjyo, Ichiko; Schambach, Felix; Intlekofer, Andrew M.; Banerjee, Arnob; Longworth, Sarah A.; Vinup, Kristine E.; Mrass, Paul; Oliaro, Jane; Killeen, Nigel P.; Orange, Jordan S.; Russell, Sarah M.; Weninger, Wolfgang J.; Reiner, Steven L.
Abstract: A hallmark of mammalian immunity is the heterogeneity of cell fate that exists among pathogen-experienced lymphocytes. We show that a dividing T lymphocyte initially responding to a microbe exhibits unequal partitioning of proteins that mediate signaling, cell fate specification, and asymmetric cell division. Asymmetric segregation of determinants appears to be coordinated by prolonged interaction between the T cell and its antigen-presenting cell before division. Additionally, the first two daughter T cells displayed phenotypic and functional indicators of being differentially fated toward effector and memory lineages. These results suggest a mechanism by which a single lymphocyte can apportion diverse cell fates necessary for adaptive immunity.
Publication type: Journal article
Research centre: Swinburne University of Technology. Faculty of Engineering and Industrial Sciences. Centre for Micro-Photonics
Source: Science, Vol. 315, no. 5819 (2007), p. 1687-1691
Publication year: 2007
Publisher: American Association for the Advancement of Science
Format: 1687-1691
ISSN: 0036-8075
Publisher URL: http://dx.doi.org/10.1126/science.1139393
Peer reviewed