Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.3/25428

Title

Bio-reactor for in vitro evaluation of tissue engineered arteries and heart valves

Author(s)

Morsi, Yos S.;  Yang, W.;  Wong, Cynthia S.;  Owida, Amal A.

Abstract

Arterial bypass and heart valve replacements are two of the most common surgical treatments in cardiovascular surgery today. Currently, artificial materials are used as substitute for these cardiac tissues. However, these foreign materials do not have the ability to grow, repair or remodel and are thrombogenic, which leads to stenosis. With the aid of tissue engineering, it is possible to develop functional identical copies of healthy heart valves and arteries which are biocompatible. In this paper, we discussed the design concept, criteria and the development of a multi-functional bioreactor for tissue culture. This system is capable of providing physiological pressure and flow of nutrient medium for arteries and heart valves. The developed system is compact and can be placed in an incubator to provide a typical cellular growth environment. Moreover, the proposed reactor design, in addition to mimicking conditions in vivo, is highly flexible, allowing different types of tissues, arteries and heart valves to be engineered under various haemodynamic stresses. Initial verification and haemodynamic testing on fluid flow using Laser Doppler and Particle Images Velocimetry indicated that the bioreactor performed well and is producing the correct physics expected.

Publication type

Conference paper

Research centre

Swinburne University of Technology. Faculty of Engineering and Industrial Sciences. Industrial Research Institute Swinburne

Source

Proceedings XVth International Conference on Mechanics in Medicine and Biology (ICMMB-15 2006), Singapore, 06-08 December 2006, p. 74-76

Publication year

2006

Publisher

Nanyang Technological University

ISBN

1930746059