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Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.3/708
- Title
- Comparison of penetration depth between two-photon excitation and single-photon excitation in imaging through turbid tissue media
- Author(s)
-
Gu, Min;
Gan, Xiaosong;
Kisteman, Aernout;
Xu, Ming G.
- Abstract
- We show, both theoretically and experimentally, that for a turbid tissue medium where Mie scattering is dominant, multiple scattering not only reduces the illumination power in the forward direction but also exhibits an anisotropic distribution of scattered photons. Thus, a signal level under two-photon excitation drops much faster than that under single-photon excitation although image resolution is much higher in the former case. As a result, the penetration depth under two-photon excitation is limited by the strength of two-photon fluorescence and is not necessarily larger than that under single-photon excitation.
- Publication type
- Journal article
- Research centre
- Swinburne University of Technology. School of Biophysical Sciences and Electrical Engineering. Centre for Micro-Photonics
- Source
- Applied Physics Letters, Vol. 77, no. 10 (Sept. 2000), pp. 1551-1553
- Publication year
- 2000
- Publisher
- American Institute of Physics
- Language
- English
- Publisher URL
- http://dx.doi.org/10.1063/1.1308059
- Copyright
- Copyright © 2000 American Institute of Physics. Reproduced in accordance with the copyright policy of the publisher.
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