The acquired immune system provides a microcosm of Darwinian natural selection at the cellular level. When more than one of these somatic learning systems is considered in a population, an array of interesting effects and interactions become apparent. This work elaborates on a series of multiple immune system models defined in a previous work. A framework for such models is presented that defines mechanisms such as pathogen exposure regimes, immune effector sharing schemes, and evolutionary mechanisms. The previously defined models are re-defined using this framework, although the models described represent a small fraction of the combinations of the defined mechanisms.