Fabrication and biofunctionalization of selenium-polypyrrole core-shell nanoparticles for targeting and imaging of cancer cells

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Title: Fabrication and biofunctionalization of selenium-polypyrrole core-shell nanoparticles for targeting and imaging of cancer cells
Author(s): Li, Jing-Liang; Liu, Xiang-Yan
Abstract: Selenium-polypyrrole core-shell nanoparticles are fabricated by an in-situ polymerization process and functionalized with transferrin for targeting and imaging of human cervical cancer cells. The shell thickness and chemical composition of the as-synthesized particles can be manipulated by controlling the precursor concentration. The presence of the polymer layer can greatly increase the thermal stability of the selenium nanoparticles. The presence of transferrin molecules on the surface of the core-shell nanoparticles can significantly enhance their cellular uptake. The tranferrin-conjugated core-shell nanoparticles can be potentially used for the targeting and imaging of cancer cells.
Publication type: Journal article
Research centre: Swinburne University of Technology. Faculty of Engineering and Industrial Sciences. Centre for Micro-Photonics
Source: Journal of Nanoscience and Nanotechnology, Vol. 8, no. 5 (May 2008), pp. 2488-2491
Publication year: 2008
Keyword(s): Cancer cells; Nanoparticle; Polypyrrole; Selenium; Transferrin
Publisher: American Scientific Publishers
ISSN: 1533-4880
Publisher URL: http://dx.doi.org/10.1166/jnn.2008.502
Copyright: Copyright © 2008 American Scientific Publishers. All Rights Reserved. The publisher does not allow institutions to archive either the accepted manuscript or the published version of the article.
Peer reviewed