The relationship between oxidized low-density lipoprotein/beta 2 glycoprotein 1 complexes and traditional risk factors in relation to coronary artery calcium


Vivian, Lee; Ling, Cham Yee; San, Hwang Siaw; Matsuura, Eiji; Bhave, Mrinal; Said, Asri bin; Sin, Khaw Chee; Zan, Khiew Ning; Tat, Koh Keng; Amin, Nor Hanim Md; Kiam, Ong Tiong; Yee, Oon Yen; Yen, Voon Chi; Yip, Alan Fong Yean


Background: Coronary artery calcium (CAC) score, as a marker that refines risk assessment of coronary artery disease (CAD) beyond traditional risk factors, corresponds to atherosclerotic burden in the coronary arterial vasculature. Oxidized low density lipoprotein/beta 2 glycoprotein 1 (oxLDL/β2GP1) complexes have proatherogenic roles implicated in systemic inflammation, autoimmune disease and acute coronary syndrome. It remains unknown how this complex relates to CAC. Objective: We sought to determine whether circulating plasma oxLDL/β2GP1 levels are associated with CAC and other known cardiovascular risk factors. Materials & methods: We conducted a single-center prospective observational study recruiting 384 patients with suspected coronary artery disease (CAD) undergoing CCTA. Coronary calcification was assessed using the Agatston score obtained from a dual source computed tomography (DSCT) scanner. Circulating levels of oxLDL/β2GP1 were measured using enzyme linked immunosorbent assay (ELISA) using a duplicate analysis method. Results: An abnormal CAC (score > 0) was found in 49.1% of study cohort. The mean value of oxLDL/β2GP1 in our cohort was 21.61±1.41 units/ml. Bivariate correlation revealed that oxLDL/β2GP1 was significantly and positively correlated with body mass index (BMI) (r = 0.135, p = 0.011), HbA1c (r = 0.108, p = 0.041), total cholesterol (r = 0.201, p < 0.001) and triglyceride (TG) levels (r = 0.732, p = 0.001). Also, oxLDL/β2GP1 was negatively correlated with plasma high density lipoprotein (HDL) (r = -0.192, p < 0.001) and low-density lipoprotein (LDL) levels (r = -0.237, p < 0.001). Positive correlation was found between oxLDL/β2GP1 and CAC, nearly achieving statistical significance (r = 0106; p = 0.057). We noted that plasma levels of high-density lipoprotein (HDL) were found be to significantly lower in individuals with CAC scores above 0 (p = 0.003). Conclusion: In this pioneering study involving a multiethnic Asian population, plasma oxLDL/β2GP1 levels is associated with CAC scores, and also associated with certain known cardiovascular risk factors namely BMI, plasma total cholesterol, HDL, LDL, TG. Therefore, oxLDL/β2GP1 represents a potential new novel plasma marker of CAD.

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Conference paper


International Journal of Cardiology: NHAM (National Heart Association of Malaysia) abstracts supplement, Vol. 273, no. S, pp. 11-12




Elsevier BV


Copyright © 2018.

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