Prognostic value of leucocyte telomere length in acute myocardial infarction

Author(s)

Hui, Ho Kian; Mei, Jong Siu; Yip, Alan Fong Yean; San, Huang Siaw; Mohammad, Syed Hazran Bin Syed; Yuan, James Lee Zhi; Li, Rebecca Chew Su; Mazlan, Naemah; Tat, Koh Keng; Pbeng, Francis Shu Eng; Ting, Tan Chen; Yee, Oon Yen; Ping, Diana Foo Hui; Amin, Nor Hanim Mohd; Said, Asri; Ling, Cham Yee; Zan, Khiew Ning; Yen, Voon Chi; Kiam, Ong Tiong

Abstract

Introduction: Leucocyte telomere length (LTL) has been described as a marker of biological age, endothelial dysfunction and atherosclerosis. The association between LTL and clinical characteristics of Asian patients, and their outcomes following acute myocardial infarction (AMI) have been inconclusive. Objective: To investigate the relationship between LTL and developing AMI, the association of LTL with inpatient and 30-day mortality, and the comparison to LTL with established AMI risk scores in predicting these outcomes. Methodology: 100 patients aged 30-70 years admitted with an AMI to a tertiary referral center between May-Oct 2017 were enrolled; these were matched with 100 non-AMI ('healthy') controls for gender and age (+/- 1 year). Clinical data was obtained prospectively; inpatient and 30-day outcomes documented. LTL was reflected by a well described variable called a tis ratio (TSR). The TSR was measured at enrolment using a quantitative PCR-based methods (qPCR) and results blinded to the clinician. Results: The mean age of AMI patients was 52.2±9.4 years, and 84% were male. Both groups were well matched for ethnic distribution, past history of dyslipidemia, lipid profile and BMI. There were more active smokers, known history of hypertension, diabetes and family history of AMI in the AMI group. There was no significant difference in the LTL in AMI patients compared healthy controls (0.7946±0.0354 vs 0.7967±0.0243, p=0.619). In AMI patients, younger patients (ie < 52.2 years) had a marginally lower LTL compared to controls (0.7887±0.0459 vs 0.7903±0.0253, p=0.834). There was a 2% cardiac mortality during index admission, and at 30-day follow up, with no difference in LTL (0.811±0.0212 for cardiac mortality at 30-days vs 0.7943±0.0356, p=0.511). There was also no association between LTL with coronary disease severity. LTL had no correlation with TIMI and GRACE scores for patients admitted with AMI (For TIMI, Pearson R=0.018, p=0.861; for GRACE, Pearson R=0.033, p=0.743). Conclusion: LTL length was similar in AMI patients and healthy controls. LTL length was not associated with inpatient and 30-day outcomes, and not associated with established AMI risk prediction scores. However, LTL was shown to be shorter in younger patients with AMI - therefore further studies warranted, including longer term clinical outcomes.

Publication year

2018

Publication type

Conference paper

Source

International Journal of Cardiology: NHAM (National Heart Association of Malaysia) abstracts supplement, Vol. 273, no. S, pp. 3-3

ISSN

0167-5273

Publisher

Elsevier BV

Copyright

Copyright © 2018.

Additional information

Abstract only.

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