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Adjuvant therapy with antidepressants for the management of inflammatory bowel disease

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: Primary objectives: 1. To assess the efficacy and safety of antidepressants for managing anxiety and depression in IBD 2. To assess the efficacy and safety of antidepressants for managing quality of life in IBD. Secondary objectives: 1. To assess the efficacy and safety of antidepressants for managing disease activity in IBD.

Author: Mikocka-Walus, Antonina, Fielder, Andrea, Prady, Stephanie L., Esterma...
Publication year: 2017
Publication type: Article in Press
Status: Live|Last updated:July 21, 2017 4:32 PM
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Preparation and characterization of highly conductive polyurethane composites containing graphene and gold nanoparticles

Two series of gold nanoparticles/graphene/polyurethane composite films were prepared using a solution mixing method. The first series was of constant loading of graphene/polyurethane with varying levels of gold nanoparticles (AuNPs), while the second was of varying graphene content with constant loading of AuNPs. The electrical conductivity of the AuNPs/graphene/polyurethane composites was determined using the two-point probe method. For the first series, a maximum conductivity of 0.424 S cm −1 was achieved with a 5% AuNPs/5% graphene/polyurethane composite, and for the second, a maximum conductivity of 1.388 S cm −1 was achieved with a 5% AuNPs/15% graphene/polyurethane composite. The composites were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, differential scanning calorimetry, thermogravimetric analysis, and tensile testing methods. Tensile strengths and thermogravimetric analyses showed, respectively, acceptable mechanical properties and thermal stability of th…

Author: Al-Attabi, Nuha Y., Kaur, Gagan, Adhikari, Raju, Cass, Peter, Bown, Ma...
Publication year: 2017
Publication type: Journal article
Status: Live|Last updated:July 21, 2017 4:32 PM
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Controllable fabrication of bulk hierarchical nanoporous palladium by chemical dealloying at various temperature and its thermal coarsening

In the present study, bulk hierarchical nanoporous Pd materials (BHNPP) were successfully prepared. Results show that the microstructure of nanoporous materials can be facile tailored by optimizing the dealloying temperature and the concentration of HCl solutions. The formation mechanisms of BHNPP materials were discussed, which reveal that the nucleation and growth of Pd crystalline is essential to form nanoporous Pd. Surface diffusivities, activation energies and diffusion constants at the bimodal porous structure and the monolithic porous structure of Pd atoms were also evaluated. Furthermore, BHNPP show favorable thermal stability, ligament diameters of which is ~30 nm even after heated at 1073 K for 1 h.

Author: Kong, Qingquan, Feng, Wei, Sun, Chenghua, Liu, Ying, Lian, Lixian
Publication year: 2017
Publication type: Article in Press
Status: Live|Last updated:July 21, 2017 4:32 PM
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Phase morphology, mechanical, dynamic mechanical, crystallization, and thermal degradation properties of PP and PP/PS blends modified with SEBS elastomer

Binary and ternary blends comprised of polypropylene (PP), polystyrene (PS) and polystyrene-block-poly(ethylene-ran-butylene)-block-polystyrene (SEBS) were prepared. The effect of phase composition of minor components on the morphology, mechanical, viscoelastic, crystallization, and thermal degradation properties was studied. Binary blends exhibited inferior properties, typical of immiscible and incompatible multi-phase systems and showed matrix-droplet phase morphologies. Ternary blends, especially those with greater concentration of SEBS minor phase, exhibited interesting properties. Scanning electron micrographs of SEBS compatibilized PP/PS blends, did not show any PS particle pulling out of the PP matrix, indicating good compatibility of SEBS with PP/PS blends. Dynamic mechanical analysis also supported the heterogeneous phase structure of the blends. Thermogravimetry and differential scanning calorimetry showed that addition of PS and SEBS decreased the thermal stability of PP marginally, but shows sligh…

Author: Parameswaranpillai, Jyotishkumar, Jose, Seno, Siengchin, Suchart, Hame...
Publication year: 2017
Publication type: Journal article
Status: Live|Last updated:July 21, 2017 4:32 PM
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DSM-5 cannabis use disorder, substance use and DSM-5 specific substance-use disorders: Evaluating comorbidity in a population-based sample

Cannabis use disorder (CUD) is frequently associated with concurrent substance use and/or comorbid substance use disorders (SUDs); however there is little specificity with regard to commonly abused individual drug types/classes. This study therefore aimed to provide insight into the degree of these co-occurring relationships across several specific newer and older generation illicit and prescription drugs. 36,309 adults aged 18+ from wave 3 of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC-III) were assessed. Weighted cross-tabulations and multivariable logistic regression analyses were used to evaluate comorbidity between current DSM-5 CUD, substance use and DSM-5 SUD. Current DSM-5 CUD is associated with greater lifetime use of all examined drug classes, and previous 12-month use of several newer-class illicit and prescription stimulant-based substances (all p < 0.05). Current DSM-5 CUD was similarly associated with increased incidence of a range of DSM-5 SUDs and was independe…

Author: Hayley, Amie C., Stough, Con, Downey, Luke A.
Publication year: 2017
Publication type: Journal article
Status: Live|Last updated:July 21, 2017 4:32 PM
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Tibial impact accelerations in gait of primary school children: The effect of age and speed

Tibial stress fractures are associated with increased lower extremity loading at initial foot-ground contact, reflected in high peak positive acceleration ( > 8 g) of the tibia in adults. There is no reported data on peak positive acceleration of the tibia in children during walking and running. The aim of this study was to establish tibial peak positive acceleration responses in children across a range of age and gait speeds. Twenty-four children aged 8.5 ± 1.4 years with no known gait pathology comprised two age groups; Young (7–9 year, n = 12) and Older (10–12 years, n = 12). Wireless Inertial Measurement Unit comprising a tri-axial accelerometer was securely taped to the anteromedial aspect of the distal tibia to measure peak positive acceleration responses while walking and running on the treadmill at 3 different speeds (20% below baseline, baseline, and 20% above baseline). Results showed significant increase in peak positive acceleration with increased gait speed and greater variability in young childr…

Author: Tirosh, Oren, Orland, Guy, Eliakim, Alon, Nemet, Dan, Steinberg, Nili
Publication year: 2017
Publication type: Journal article
Status: Live|Last updated:July 21, 2017 4:32 PM
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Editorial: Optimising spectrum use

Abstract not available.

Author: Given, Jock, Cave, Martin
Publication year: 2017
Publication type: Commentary
Status: Live|Last updated:July 21, 2017 4:32 PM
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Specific targeting of TGF-β family ligands demonstrates distinct roles in the regulation of muscle mass in health and disease

The transforming growth factor-β (TGF-β) network of ligands and intracellular signaling proteins is a subject of intense interest within the field of skeletal muscle biology. To define the relative contribution of endogenous TGF-β proteins to the negative regulation of muscle mass via their activation of the Smad2/3 signaling axis, we used local injection of adeno-associated viral vectors (AAVs) encoding ligand-specific antagonists into the tibialis anterior (TA) muscles of C57BL/6 mice. Eight weeks after AAV injection, inhibition of activin A and activin B signaling produced moderate (-20%), but significant, increases in TA mass, indicating that endogenous activins repress muscle growth. Inhibiting myostatin induced a more profound increase in muscle mass (-45%), demonstrating a more prominent role for this ligand as a negative regulator of adult muscle mass. Remarkably, codelivery of activin and myostatin inhibitors induced a synergistic response, resulting in muscle mass increasing by as much as 150%. Tran…

Author: Chen, Justin L., Walton, Kelly L., Hagg, Adam, Colgan, Timothy D., Joh...
Publication year: 2017
Publication type: Journal article
Status: Live|Last updated:July 21, 2017 4:32 PM
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Investigation of the influence of FDM operating parameters on dynamic force response using IV-optimal design and principal component analysis

To improve the functionality in regards to manufacturing products at low cost, several innovative additive manufacturing processes have been developed. Fused deposition modeling (FDM) is one the most prominent additive manufacturing processes for producing plastic products. Referring to the quality and functionality, there are many FDM process conditions contributing to the occurrence of poor quality and functionality of FDM manufactured products. Therefore, the effect of the build parameters on the functionality of FDM produced products need to be examined. In this study, an attempt has also been made to investigate the critical processing parameters affecting dynamic mechanical response of plastic part processed by FDM technology using IV-optimal response surface method coupled with principal component analysis technique. The results obtained from this study can be used in the future as a guide for future in selecting the appropriate process conditions before the manufacturing process of the product take pl…

Author: Mohamed, Omar Ahmed, Masood, Syed Hasan, Bhowmik, Jahar Lal
Publication year: 2017
Publication type: Conference paper
Status: Live|Last updated:July 21, 2017 4:32 PM
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A side-sensitive modified group runs double sampling (SSMGRDS) control chart for detecting mean shifts

A side-sensitive modified group runs double sampling (SSMGRDS) chart for detecting mean shifts is proposed. The average number of observations to signal (ANOS) and expected average number of observations to signal (EANOS) performances of the SSMGRDS, (Formula presented.), double sampling (DS), side-sensitive group runs double sampling (SSGRDS), side-sensitive modified group runs (SSMGR) and exponentially weighted moving average (EWMA) charts are compared. For the zero-state case, the SSMGRDS chart outperforms all charts under comparison, for all sizes of mean shifts. For the steady-state case, the EWMA chart prevails for small and moderate mean shifts but the SSMGRDS chart prevails for large shifts.

Author: Saha, Sajal, Khoo, Michael B. C., Lee, Ming Ha, Castagliola, Philippe
Publication year: 2017
Publication type: Article in Press
Status: Live|Last updated:July 21, 2017 4:32 PM
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