Acute myocardial infarction (AMI) is characterised by a rapid increase in circulating mean platelet volume (MPV) with unknown mechanism. Large platelets are associated with adverse clinical outcomes. We investigated the mobilisation of splenic platelet store following AMI and its role in promoting inflammatory response and cardiac damage. In patients with AMI, MPV and platelet-monocyte conjugation (PMC) were determined by haematology or flow cytometry at admission, day-1 and day-3. In mice with AMI, platelet size and PMC of blood and the spleen were determined by flow cytometry. Splenectomy was performed in mice to examine the effect on platelet size, PMC, splenic platelet store, amounts of platelets and leukocytes in the infarct myocardium, infarct size and cardiac function. In patients with AMI, circulating MPV and PMC increased within 1∼3 h post-AMI and MPV returned to reference levels at day-1. In mice, increases in platelet size and PMC became evident during 12 h to 72 h. Splenic platelets are bigger tha…
Acoustics is typically considered only late in developed design or even post occupancy, if at all, for specification of finishes and furnishing, and typically with a remedial mindset. In this paper, the role of sound performance as a design driver in increasing the speech privacy of a semi-enclosed meeting space in an open plan interior is studied. Sound performance prediction is applied as an imperative input to inform the meeting space design. The design is the second iteration in an evolving series of meeting spaces, and therefore has benefited from both subjective experiments and objective measurements performed with the first meeting space prototype. This study promotes a design method that offers a strong relationship between the digital simulation of sound performance and design development. By improving the speech privacy of a meeting space by means of purely form, geometry and design decisions, the significance of architecture in tuning the sound performance of a space is investigated.
We report a measurement of the time-dependent CP asymmetry of B¯0→DCP(∗)h0 decays, where the light neutral hadron h0 is a π0, η, or ω meson, and the neutral D meson is reconstructed in the CP eigenstates K+K-, KS0π0, or KS0ω. The measurement is performed combining the final data samples collected at the (4S) resonance by the BABAR and Belle experiments at the asymmetric-energy B factories PEP-II at SLAC and KEKB at KEK, respectively. The data samples contain (471±3)×106BB¯ pairs recorded by the BABAR detector and (772±11)×106BB¯ pairs recorded by the Belle detector. We measure the CP asymmetry parameters -ηfS=+0.66±0.10(stat)±0.06(syst) and C=-0.02±0.07(stat)±0.03(syst). These results correspond to the first observation of CP violation in B¯0→DCP(∗)h0 decays. The hypothesis of no mixing-induced CP violation is excluded in these decays at the level of 5.4 standard deviations.
Ethylene-vinyl acetate copolymer (EVA) was used to toughen the hydroxyapatite/polyamide 66 (HA/PA66) composites, which were analyzed by SEM, DMA, FTIR, XRD and mechanical testing. The results indicated that the change of composition influenced significantly the properties of the composites by different mechanism, and the presence of 10 wt.% EVA could improve the impact strength of HA/PA66 composites more effectively. This was traced to the combined favorable physical characteristics of the flexibility of EVA molecular chains, more homogeneous distribution of HA in PA66 matrix, and the presence of interactions between EVA, HA and PA66.
Abstract not available.
We present an analysis of all prime HST legacy fields spanning >800 arcmin2 in the search for z ∼ 10 galaxy candidates and the study of their UV luminosity function (LF). In particular, we present new z ∼ 10 candidates selected from the full Hubble Frontier Field (HFF) data set. Despite the addition of these new fields, we find a low abundance of z ∼ 10 candidates with only nine reliable sources identified in all prime HST data sets that include the HUDF09/12, the HUDF/XDF, all of the CANDELS fields, and now the HFF survey. Based on this comprehensive search, we find that the UV luminosity function decreases by one order of magnitude from z ∼ 8 to z ∼ 10 over a four-magnitude range. This also implies a decrease of the cosmic star formation rate density by an order of magnitude within 170 Myr from z ∼ 8 to z ∼ 10. We show that this accelerated evolution compared to lower redshift can entirely be explained by the fast build up of the dark matter halo mass function at z > 8. Consequently, the predicted UV LFs fr…
Basket weaving. It doesn’t sound much of an insult does it? But Education Minister Simon Birmingham appeared to use the term in this way in an interview following opposition leader Bill Shorten’s budget reply speech. Birmingham reacted disdainfully to Shorten’s commitment to fund fees for TAFE students, sneering at Labor’s “disastrous VET FEE-HELP program that subsidised everything from energy healing to basket weaving.” Shadow treasurer Chris Bowen described this comment as an insult to TAFE teachers. Bowen is right, of course. But more than that, this insult derives its power from denigrating and trivialising crafts traditionally practised by women. By extension, it denigrates women themselves.
It’s been a big year for companies pushing the boundaries of technology – and not in a good way. The Cambridge Analytica scandal led to a public outcry about privacy, the Commonwealth Bank’s loss of customer data raised concerns about cybersecurity, and a fatal self-driving car crash put the safety of automated systems in the spotlight. These controversies are just the latest warning signs that we urgently need better governance of the technologies redefining the world. There is a widening gap in knowledge between those creating and using emerging technologies and those we charge with regulating them. Governance cannot be left just to the public sector – it is a job for all citizens.
This book brings together world experts in the field of Functional Gastrointestinal Disorders (FGIDs) who practice an integrated and holistic approach in their care for patients to provide an up-to-date and comprehensive evaluation of a range of issues associated with the biopsychosocial treatment of FGIDs. Examining topics such as neurological and biological aspects of FGIDs, common concerns faced in relation to diagnosis, and ongoing medical decisions and interventions, each chapter provides crucial practical recommendations, as well as future directions of psychosocial work in multi-team environments.
BACKGROUND: Incentives are often used to enhance the effectiveness of recruitment and retention campaigns targeting blood donors. However, the degree to which incentives succeed in attracting and facilitating repeat donation is unclear. A systematic literature review, following PRISMA guidelines, investigated the existing empirical evidence regarding the use of monetary and nonmonetary incentives within blood donation. STUDY DESIGN AND METHODS: A comprehensive search of relevant databases identified a total of 71 papers for inclusion in the review for defining and operationalizing incentives (Objective 1), of which nine papers empirically investigated attitudes toward incentives (Objective 2), 31 papers investigated the impact on blood donation behavior (Objective 3), and eight papers investigated the impact on blood safety (Objective 4). RESULTS: Overall, research into the use of incentives in blood donation is limited, characterized by comparatively few studies, predominantly focused on whole blood donors, …